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Nutrition and Gastroenterology

Hauschild DB, Rosa AF, Ventura JC, Barbosa E, Moreira EAM, Ludwig Neto N, Moreno YMF. 

Rev Paul Pediatr. 2018 Jan 15;36(1):8. doi: 10.1590/1984-0462/;2018;36;1;00006. PMID: 29412427; PMCID: PMC5849371.


To evaluate the association between nutritional status, lung function and morbidity in a 36-month cohort in children and adolescents with cystic fibrosis.
Prospective cohort of children and adolescents with cystic fibrosis aged 1-15 years. At the baseline, the nutritional status was determined by weight-for-height and body mass index-for-age for children <2 years and >=2 years, respectively, and classified as: nutritional failure, nutritional risk and acceptable; and by the 50th percentile, according to the World Health Organization (WHO) growth charts. Lung function was assessed by forced expiratory volume in one second (FEV1). Morbidity was determined by the presence of infection and hospitalization by pulmonary exacerbation. Risk ratio and 95% confidence interval (95%CI) were calculated, being significant when p<0.05.
We evaluated 38 children and adolescents (median age 3.8 years). Patients that were classified as having nutritional failure at baseline had a RR of 5.00 (95%CI 1.49; 16.76) to present impaired lung function after 36 months. Those classified bellow the 50th percentile had a RR of 4.61 (95%CI 0.89; 23.81) to present the same outcome. Nutritional status was not a risk factor for morbidity in this cohort.
Nutritional deficit was associated with impaired lung function, but not with morbidity in children and adolescents with cystic fibrosis.
Keywords: Cystic fibrosis, nutritional status, spirometry, cohort studies, pediatrics.

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Fiates GMR, Barbosa E, Auler F, Feiten SF, Miranda F

Rev Nutr Campinas. 2001;14(2):95-101.

Cystic fibrosis affects nutritional status because it interferes with adequate ingestion and absorption of nutrients. The present study evaluated 22 fibrocystic patients, who attended ambulatory visits at Hospital Infantil Joana de Gusmão, in the city of Florianópolis, Santa Catarina, Brazil, from August 1998 to January 1999. Nutritional status was determined by anthropometric measurements and food intake data. As to the nutritional status, 42.9% of the children under 2 years old and 28.6% over 10 years old were malnourished. Children between 2-10 years old did not present malnutrition. Evaluation of nutritional intake showed that 33.3% were eating adequate amounts of energy, and 95.2% of protein. It can be concluded that cystic fibrosis affects nutritional status of children in critical periods of growth and development, and that the quality of their diets can benefit from adequate nutritional care.
Keywords: Nutrition, cystic fibrosis, nutrition assessment, eating, child.